Myotonic Dystrophy Type 2. The specific kinds of mutations found in both types of myotonic dystrophy are trinucleotide repeat expansionsThese types of mutations occur when a piece of DNA is abnormally repeated a number of times which makes the gene unstable. Myotonic dystrophy type 2.
Muscle biopsy showing mild myopathic changes and grouping of atrophic fast fibres type 2 highlighted. The repeat length may diminish with generational transmission. DM2 is an important diagnosis to consider in patients who have proximal muscle weakness around.
Myo means muscles muscles are affected tonia meaning tension the tension of the muscle is affected.
Muscle biopsy showing mild myopathic changes and grouping of atrophic fast fibres type 2 highlighted. The repeat length may diminish with generational transmission. Immunohistochemical staining for type-1 slow myosin. MYOTONIC DYSTROPHY TYPE 2 DM2 The onset of DM2 is typically in the third decade but anywhere between the second and sixth decade of life is common.
